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Most men with CF ( percent) are infertile because of a blockage or absence of the sperm canal, known as congenital bilateral absence of the vas deferens (CBAVD). The sperm never make it into the semen, making it impossible for them to reach and fertilize an egg through intercourse. Normally the vas deferens carries the newly made sperm to the back of the prostate Leeds Regional Adult and Paediatric Cystic Fibrosis Units, St James's.